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[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent

An aminoisobutyric acid (Aib) substitution at position 8 resists degradation by the DPP-4 enzyme

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(PubMed) Dangour AD, Allen E, Clarke R, et al