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Although more animals receiving checkpoint blockade succumbed to diabetes than PFK15 + IgG treated animals, diabetes incidence between these two groups were not statistically significant (p = 0.348), indicating an inability to reverse PFK15 induced T cell exhaustion

Both are worth investigating, though for different reasons

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Excess cholesterol can form plaque in artery walls, making it harder for your heart to pump and circulate blood, and plaque can cause blood clots, which can cause a stroke