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These approaches included anti-IGF-1R monoclonal antibodies (mAbs), IGF-1R tyrosine kinase inhibitors (TKIs), IGF-1/2 blocking mAbs, IGF ligand-TRAPs, recombinant IGFBPs and pregnancy-associated plasma protein-A (PAPP-A) inhibition [54,55]

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[DOI] [PubMed] [Google Scholar] [27].Singh RP, La Cava A, Hahn BH

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Current Uncertainties and Future Challenges Regarding NAD+ Boosting in the Context of Brain Aging and Dementia

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Beyond 48 hours, potency loss becomes measurable

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