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A randomized, double-blind, placebo-controlled, stratified trial of riluzole 100 mg daily, given as 50 mg twice daily, demonstrated a statistically significant survival benefit at 12 and 21 months, with median survival increasing by 83 days [113], with more robust survival effect seen in patients with bulbar onset disease

The lack of comprehensive long-term studies necessitates a cautious approach to extended treatment protocols

Your prescribed injection method and dosage are determined by your doctor and provided by your pharmacy

While caution is warranted when manipulating global -syn levels, we conclude that targeting toxic -syn seems a compelling strategy for therapeutic targets in PD

10.2174/138620712802650522 82 GeorgetM.PisanE

Hall MJ, Levant S, DeFrances CJ