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Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus

By employing genome-scale metabolic reconstruction and biodomain enrichment, the authors identified a core set of 62 genes and specific metabolite-gene pairings, such as MTHFR-homocysteine and PDHA1-acetyl-CoA, that drive pathological metabolic flux

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The above experiments in vivo and in vitro have confirmed that TMAO can cause inflammation of endothelial cells, and similar results can be observed in humans