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Int J Pharm 640:123034

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Severe malnutrition could lead to muscle wasting while disturbances in electrolyte balance could lead to muscle cramping, changes in mental status, and irregular heart rhythms

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Metabolism One of MTXs main metabolites, 7-hydroxymethotrexate (7-OH-MTX), is produced by the liver during the first-pass metabolism of MTX (Seideman et al

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