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doi: 10.1371/journal.ppat.1001248 29 NathansonCMWasseliusJWallinHAbrahamsonM

This study revealed a significant increase in uric acid levels from 10 to day 60, along with congestion in renal tissue and interstitial neutrophil infiltration

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Similarly to women, melatonin causes a decrease in LH secretion, leading to lower testosterone secretion by Leydig cells in the testes, which has a negative impact on the intensity of spermatogenesis (107)

Cluster analysis, visualized through a heatmap, and annotation of the top differentially regulated metabolites (Figure 5B) provided insights into the metabolic shifts

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