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However, the REGARD trial analysis found that the prognostic trend between high VEGFR-2 endothelial expression and shortened progression-free survival was not significant

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Up-regulating SreBP-1 expression raises the activities of fatty acid synthase and acetyl coenzyme A carboxylase, which stimulates the production of fatty acids and cholesterol and causes abnormal lipid buildup in renal tubular cells[41]

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