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Foundational clinical-trial data points include the SUSTAIN-1 trial for type 2 diabetes (PMID 28110911) and the STEP-1 trial for obesity (PMID 33567185), both of which documented body-weight and glycemic outcomes against placebo

The application of NaBPC157 leads to significantly reduced pathomorphological findings of antracyclin cardiomyopathy (severe damage of myocytes and vessel walls, and vacuolisation) after single, and in greater extent, after multiple doxorubicin administration

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Next, we assessed whether AgRP GHR KO mice exhibit a normal endocrine response to weight loss