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These framework substitutions are identified by methods well known in the art, e.g., by modeling of the interactions of the CDR and framework residues to identify framework residues important for antigen binding and sequence comparison to identify unusual framework residues at particular positions

doi: 10.1186/s40168-016-0171-4 224 GuoCCheXBrieseTRanjanAAllicockOYatesRAet al

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Relative protein abundance was calculated as the ratio of abundance determined by the TMT tags

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