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The roles of vitamin A and its derivatives in the pathogenesis and pathophysiology, as well as their potential therapeutic effects in neurodegenerative diseases such as PD, have been studied by many researchers

Among them, inflammatory cytokines such as interleukin (IL)-6, IL-8, tumor necrosis factor- (TNF-), IL-1 and cyclooxygenase-2 contribute to the development of chronic inflammatory diseases (22)

Host-microbe interactions and network analysis As previously discussed, hostmicrobe interactions are crucial for maintaining skin immunity, barrier function, and overall homeostasis, and defending against pathogens

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3.5 High mobility group box 1 and inflammatory signaling HMGB1, a nuclear protein, functions as a transcription factor and a DAMP that amplifies inflammatory responses (45)