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The induction of ferroptosis in vivo by BSO&OXA@MOF-LR was further verified by adding a combination of BSO&OXA@MOF-LR and the ferroptosis inhibitor deferoxamine, which resulted in significantly decreased tumor suppression when compared with that of BSO&OXA@MOF-LR (Fig

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[116] [17] On the other hand, sodium channel blockade is also thought to contribute to the analgesic effects of TCAs, for instance in the treatment of neuropathic pain

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Aroeira R.I., Sebastio A.M., Valente C.A

[6] [9] In addition to the UGA-codon, a cis-acting element in the mRNA, called SECIS, binds SBP2 to recruit other proteins, such as eukaryotic elongation factor selenocysteine-tRNA specific, to form the complex responsible for the recoding process