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The dose of NAC used in clinical trials ranges from about 600 mg to 3,000 mg per day, typically divided into 2 or 3 doses

Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work

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Osthole promotes PASMCs apoptosis by modifying Bax/Bcl-2-caspase 3 signal pathway and inhibits PASMCs proliferation by regulating TGF-1/Smad/p38 signaling pathway [9, 10]

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