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(2021) clearly indicated that hydrogen-saturated saline mediates neuroprotection through autophagy via the PI3K/AKT/mTOR pathway during the early and medium stages of rotenone-induced PD in rats

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Serine-driven mitochondrial metabolism contributes to 5-FU resistance by supporting purine nucleotide biosynthesis, thereby facilitating the repair of chemotherapy-induced DNA damage 154

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Strengthens Immune Function - Low glutathione levels have been directly linked to weakened immune response

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doi: 10.1056/NEJMra0801327 10 BurbullaL

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However, in the SW620/Ad300 (P-gp-overexpressing) and S1-M1-80 (ABCG2-overexpressing) colon cancer xenograft models, the combination of regorafenib and paclitaxel or the combination of regorafenib and topotecan resulted in a synergistic antitumor effect which demonstrated that regorafenib overcame the resistance of paclitaxel to P-gp-overexpressing SW620/Ad300 tumors and the resistance of topotecan to ABCG2-overexpressing S1-M1-80 tumors in mice (Wang et al., 2017b

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