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RNA-seq and subsequent gene set enrichment analysis (GSEA) revealed that the liver tissue from Gclc KO mice was enriched in several gene signatures associated with stress responses, including those related to the activation of NRF2 (Fig

Statistical significance was calculated by one-way ANOVA in a and two-way ANOVA followed by Dunnetts multiple comparisons test with Bmal1-KO mice set as the reference group in b