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In humans, a study on a cohort of 49 healthy elderly subjects reported that the subjects maintained on a regimen of dietary restriction, in comparison to subjects maintained on ab libitum diet, exhibited enhanced verbal memory, albeit without increased serum levels of BDNF [182]

This translates to a potential reduction in hyperpigmentation and the appearance of melasma patches

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GPX4 is a major regulator of this form of programmed cell death, which is further exacerbated in cancers where recent studies have shown GPX4 as essential in some tumors [55,61]

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