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Measuring concentrations of NAAG in blood plasma samples from brain tumor patients, the investigators found significantly higher NAAG concentrations in samples from patients who had glioblastoma multiforme, the most aggressive brain cancer, than in patients who had gliomas or meningiomas

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Studies have shown that under ferroptosis-inducing conditions, the PI3K/Akt pathway may become abnormally activated, resulting in excessive amplification of survival signals and subsequently affecting cell death decisions (Yu et al

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