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Effects of isolated maternal hypothyroxinemia on adverse pregnancy outcomes

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Lost to follow-up Twenty-two males (22% of the total of 98) were lost to follow-up: 6 were treated for less than 6 months and 16 were lost at 10 to 14.4 years of age

Alterations in DNA methylation patterns lead to the dysregulation of multiple cell death pathways

A third possibility involves cytosolic degradation of GS-conjugates although evidence for appreciable accumulation of these compounds in this compartment is lacking