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Cook SF, Stockmann C, Samiee-Zafarghandy S et al , Neonatal maturation of paracetamol (acetaminophen) glucuronidation, sulfation, and oxidation based on a parent-metabolite population pharmacokinetic model

doi: 10.1056/NEJMoa1602252 219 PostowMAChesneyJPavlickACRobertCGrossmannKMcDermottDet al

Because of the immense physiological and pharmacological importance of Mrp1, there is increasing interest to understand its substrate-dependent transport mechanism and to identify modulators of Mrp1 activity and function [5, 14]

We still have not clearly revealed the mechanism about increased p53 redistribution from cytoplasm to nuclei of stress-induced hepatocytes

In this context, the present work evaluated the applicability of the commercially available upper MucilAir-HF and lower EpiAlveolar human lung models to be used as in vitro systems within a NAM toolbox to identify the bioactivity (i.e., in vitro PoD derivation) and risk of materials that may reach the respiratory tract and induce lung toxicity

Mucosal immunity in the urinary tract: changes in sIgA, FSC and total IgA with age and in urinary tract infection