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Microglia are under circadian clock control, with robust hippocampal TNF, IL1, and IL6 expression, peaking during the light or inactive phase in male Sprague-Dawley rats, with increased cytokine expression in response to an immune stimulation with lipopolysaccharide (LPS) during the light/inactive phase ( Bmal1 expression (Takano et al., 2009), along with a circadian variation in markers involved in oxidation, NADPH oxidase 2 (Nox2), and inflammatory TNF, IL1 and IL-6 in microglia increased during the light or inactive phase in nocturnal mice

Interestingly, cotreatment with both hepatokines exerted additive inhibitory effects on adipocytes but not on myotubes, suggesting potential tissue-specific differences in signaling integration or pathway saturation

Seim, A

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Cancer 19 , 38 (2020)