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The signal changed less than 10% for standards prepared in MCTS extracts or in culture medium (Supplemental Figure 9), indicating that the matrix effect did not significantly affect the signal response of the target analyte Pt-DDTC

The moderate-risk group received oral NAC (80 mg/kg/day, days 07, then 40 mg/kg/day until 37 weeks or delivery)

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N-acetyl serotonin is converted into melatonin (N-acetyl-5-methoxy-tryptamine) by being methylated with the catalysis of 5-hydroxyindole-o-methyltransferase enzyme (Figure 3) [28, 35, 36]