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The Central Role of Glutathione in the Pathophysiology of Human Diseases While these studies collectively demonstrate strong mechanistic rationale and promising early clinical observations, they also consistently acknowledge that large-scale, condition-specific randomized controlled trials are still limited

For example, the biological half-life of Fer-1 is only a few minutes, which is generally unacceptable for clinical applications
To validate this property in rats, Wistar rats were subjected to -irradiation, and the apoptosis rate of their splenic lymphocytes was assessed

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Approval was granted for all related experiments by the Institutional Ethics Committee (IEC), National Institute of Pathology, New Delhi, India
