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Enhancing the mitochondria-ER contact by increasing MFN2 level in CD8 + T cells improves the efficacy of cancer immunotherapy, reveals a buffering mechanism that regulates metabolic adaptations in tumor-infiltrating CD8 + T cells, and highlights the therapeutic potential of optimizing T cell function by increasing MFN2 expression (Yang 2023)
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Research published in the Journal of Applied Physiology showed enhanced tendon healing with improved biomechanical properties
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