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Chronic BDNF treatment has been comparatively less investigated, besides it may represent a therapeutic option to obtain rescue of post-injury alterations of synaptic networks

27,28 The SWItch/Sucrose NonFermentable (SWI/SNF) complex also plays a significant role in the precise activation and repression of tissue-specific transcription factors, functioning as a chromatin remodeler that orchestrates the coordinated differentiation of multiple cell lineages during development

Abstract Aims/hypothesis Metformin, a mainstay of treatment for type 2 diabetes, can cause vitamin B 12 deficiency

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Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death