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This is possible due to cysteine residues present on KEAP1 that can be oxidized and prevent the otherwise inevitable ubiquitination and degradation of NRF2

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Sodium taurocholate co-transporting polypeptide deficiency attenuates acetaminophen-induced hepatotoxicity via regulating expression of drug metabolism enzymes in mice

doi: 10.1007/s00253-008-1703-z

All animal housing and handling were conducted in compliance with the guidelines of Southeast University and the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No