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Description
Abnormally elevated levels of DRP1 not only cause mitochondrial fission, mitochondrial fragmentation, and decreased efficiency of mitochondrial ATP production but also impede glucose uptake (104) and glucose-stimulated insulin secretion by inhibiting the translocation of the insulin receptor substrate 1-protein kinase B (IRS1-Akt) pathway and glucose transport proteins in mouse pancreatic -cells (105)

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Several mutations in genes involved in LDL-C homeostasis leading to elevated plasma LDL-C levels (typically in the context of familial hypercholesterolaemia [FH]) are closely associated with progressive, early-onset CAD17 , 18

A., VanGilder, R

PMID 12622785

2009;15:1537-47.[PubMed Abstract] - 78.White DL, Ratziu V, El-Serag HB