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J., Li Y., et al., GlucagonLike Peptide1 (GLP1) Receptor Agonists and Neuroinflammation: Implications for Neurodegenerative Disease Treatment, Pharmacological Research 186 (2022): 106550
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A first mechanism is the direct interaction with the reducing thiolate, leading to irreversible inactivation of the active site, as described for the inactivation of GSTs (Scheme 9)
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