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10.1104/pp.106.077982 9 CannonM

doi:10.1089/thy.2016.0635 [7] Costantini A, Pala MI

Ojanpera I, Kolmonen M, Pelander A

Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor

It can activate SIRT3 to inhibit the TGF-1/Smad signaling pathway, thereby reducing the activation and migration of MF, promoting mitochondrial fusion, regulating fatty acid metabolism, and improving UUO-induced RF

In young rats, a diet rich in n-6 PUFAs can induce fatty liver, inflammation, and even liver fibrosis, and LA can influence these effects
