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Intrinsic factors and cell-autonomous insulin resistance In vitro approaches, where cells are cultured under controlled conditions, provides an opportunity to minimise the influence of extrinsic factors and isolate cell-autonomous determinants of insulin resistance, which are more closely linked to the genetic and epigenetic alterations underlying type 2 diabetes

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C., Primavera, A

Furthermore, both preterm and term infants exhibit decreased activity and expression of the placental physiological barrier 11-HSD2 (278281), consistent with the proposed increased cortisol bioavailability

An antioxidant substance or extract is said to be more effective at scavenging radicals when it has a lower IC 50 , hence, the lower the IC 50 value, the higher the antioxidant activity 72