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62, 206209.10.1016/j.neures.2008.07.005 41 CarrL

The mechanism of action of biguanides: new answers to a complex question

Although there is no cure for HD, natural compounds have demonstrated potential in preclinical research by providing neuroprotective effects via various mechanisms

Redox control at the level of methionine biosynthesis Enzymes catalyzing the two first steps of methionine synthesis, i.e., CGS and CBL, are present only in chloroplasts and are encoded by a single gene while MS are encoded by three genes, with two isoforms being expressed in the cytosol (MS1 and MS2) and one in chloroplasts (MS3) (Figure 1

Mizugaki A, et al

It plays an essential role in: Liposomal glutathione uses small phospholipid-based vesicles ( liposomes ), which are liposome-based, to trap glutathione and thus protect it during digestion and facilitate its delivery