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It must be noted, however, that CuES metalates cuproenzymes in other cellular compartments such as the Golgi (Guthrie et al., 2020)

10.3233/JPD-2012-11052 J
Homogeneous Add-Mix-Read Assay for Total and Oxidized Glutathione A wide variety of compounds can induce intracellular formation of reactive oxygen species (ROS) and the resulting cellular damage can eventually lead to apoptosis or necrosis

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Tamaki H, Amino N, Kimura M, Hidaka Y, Takeoka K, Miyai K
Biomass fuel induces neuroinflammation and neurodegeneration via the astrocyte-microglia IL-17A/IL-17RA pathway
