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Collagen types I & II are abundant in the disc, and their denaturation is indicative of proteolytic cleavage 7 and mechanical overloading 2,6

However, injectable applications require consideration of total copper load, particularly in patients with conditions affecting copper metabolism such as Wilsons disease or Menkes disease

In conclusion, this paper study highlights the role of PDFV and VCAM-1, the precursor protein of PDFV, in OvE disease progression

Such condition should also guide clinicians to prescribe the appropriate type and dosage of DOAC, without the laboratory monitoring of their anticoagulant activity