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The human lung is a well-aerated site, however, in some cases, such as CF, low mucociliary clearance, and thickened mucus form localized depletion of oxygen to permit overgrowth of bacteria in the human lung (Wu et al

This structural feature enables the cells to balance the efficiency of material exchange with the selectivity of the barrier (Wu Q

doi: 10.2466/pms.2003.97.3f.1049

Taken together these results, regarding the mechanism of dialysis-related fatigue, we speculate that glycolysis and fatty acid synthesis may be enhanced, at least partly, as compensatory mechanisms for ATP production in a state where mitochondrial function is impaired, as reported elsewhere 38

In addition, the use of AKT inhibitors in combination with extracellular asparagine (ASN) depletion can significantly inhibit tumor growth (Fig

Anderson P.H