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The field needs validated, in vivocompatible flux sensors (O 2 , H 2 O 2 , NO/ONOO ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, m, pH) to disambiguate signalling pulses from damage plateaus

Synthetic cannabimimetics (e.g., Spice, JW) also pose a great risk to users and athletes

Data availability The datasets used during the current study are available from the corresponding author on reasonable request

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Shore, G

Schreiberov M, Vlaskov L, Vlek O, Mejdov J, Horlek J, Bieser JJA