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Qian, J., & Sep

The enhancement of glycolytic pathways holds promise for early intervention

The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

These compounds, when produced in larger quantities under stress, can lead to extensive damage of DNA, proteins, and plasma/organelle membranes in the cell (Olinski et al., 1992

3a, b, Supplementary Fig

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