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Homocysteine is formed when SAMe, an important methyl donor, gives its methyl group to one of the following enzymes: GAMT to make creatine PEMT to make phospholipids COMT to metabolize estrogen HNMT to eliminate histamine PNMT to make epinephrine/adrenalin ASMT to make melatonin Because of this methyl group donation, SAMe becomes SAH
Klotho is synthesized and secreted by the distal tubule
Takagi T., Naito Y., Mizushima K., Hirai Y., Harusato A., Okayama T., Katada K., Kamada K., Uchiyama K., Handa O., Ishikawa T., Itoh Y., J Clin Biochem Nutr 2018, 63, 169
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