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Mitochondrial dysfunction - the beginning of the end in Alzheimers disease

doi: 10.1016/j.cell.2022.08.005 10 ZhangSGangXYangSCuiMSunLLiZet al

Continuous treatment with anti-BTK and anti-BCL-2 therapies is typically required in the management of CLL, and the success of these therapies is heavily dependent on the emergence of drug resistance over time

Common pitfalls with cell viability assays are: Traditional workflows are labor-intensive and difficult to scale Wash steps, sample manipulation and specialized instrumentation limit throughput and add variability Single endpoint measurements can miss the activation window and misrepresent whats actually happening Questions & Solutions Is my compound toxic to cells

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The Evidence Reality Preclinical neuroscience: BPC-157 has demonstrated effects on neurotransmitter systems in animal studies