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Mitochondrial injury in MASLD is primarily driven by overnutrition, lipotoxicity, and IR ( The link with gut-liver axis dysregulation is an area of active research

Besides, Grx2 is resistant to oxidative inactivation [167] and successfully functions as an alternative reducing system of Trx1 in the cytosol and Trx2 in mitochondria under the action of inhibitors of thioredoxin reductase

One of the included studies demonstrated that patients with malaria and sickle cell disease experienced severe oxidative stress 32

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We further investigated whether the attenuated transactivation activity (Fig

once daily for 14 days