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Endocrine Reviews 26(1):114-146. [doi.org]

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doi: 10.1016/j.cell.2007.01.045 66 IssaHEidAHBerryBTakhvijiVKhosraviAMantashSet al

Advances in biomarkers for the early diagnosis of prostate cancer

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Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors