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Functional assays evaluated LDHB-K58R (delactylation mimic) effects on proliferation, invasion, GSH levels, cystine uptake, STAT1/SLC7A11/GPX4 expression, and RSL3-induced ferroptosis in vitro

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doi: 10.3389/fcvm.2025.1545231 Received 14 December 2024 Accepted 31 March 2025 Published 16 April 2025 Volume 12 - 2025 Edited by Xintian Cai, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, China Reviewed by Qiyao Xu, Nanjing University of Chinese Medicine, China Di Shen, People's Hospital of Xinjiang Uygur Autonomous Region, China Updates Copyright 2025 Liu, Yu, Lu, Liu, Chen and Li

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Quite notably, misfolding of SOD1 could occur in the healthy elderly, and the humoral immune response to the misfolded SOD1 would be a key to prevent ALS