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304 , 761 A major barrier is that cognitive assessments take time and training to administer, interpret, document and follow up on, which can make them hard to implement in primary care practice settings

When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested

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There is an inverse relationship between them

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