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3B), as immune cells generate ROS as a primary defense mechanism against invading pathogens

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At low micromolar concentrations, inhibition of ALDH2 by 4-HNE is reversible, but at higher concentrations, when the active site thiols are covalently modified, inhibition becomes irreversible (136)

In resting cells, cofilin-1 directly bound NLRP3, but after stimulation with NLRP3 inflammasome activators, it was oxidized by ROS and dissociated from NLRP3

Regulatory frameworks for nanoparticle reproductive toxicity need integration

Our study showed that folic acid supplementation can promote the expression of SLC25A32 and MTHFD2, which are key enzymes in mitochondrial folate metabolism