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First, the Protein Data Bank ( was used to download the SIRT1 crystal structure ( PDB code: 4ZZJ )

Comparatively low GR activity allows appropriate changes in GSSG to mediate a signaling function ( B

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Possible explanatory mechanisms include resveratrols direct antioxidant properties, its indirect antioxidant effects through augmentation of glutathione, or resveratrol-mediated increases in expression of superoxide dismutase and catalase [31]