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Consistency matters with long-acting peptides

Over activation of NMDARs under excitotoxic conditions provokes Ca 2+ influx which results in activation of nNOS via calmodulin (Schrammel et al., 2003

Chronic inflammation causes mitochondrial dysfunction and necrotic swelling

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Molecular docking of DEHP with key targets Molecular docking was utilized to estimate the affinity between DEHP and the key targets

Moreover, the increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) in endothelial cells due to systemic inflammation might alter claudins and occludins, which are critical structural components of the BBB