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High triglyceride levels lead to increased production of very-low-density lipoproteins (VLDL), which are metabolized into smaller, denser LDL particles

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A growing number of animal studies provided evidence for the multifaceted mechanisms, by which l-carnitine exerts its beneficial action on increased protein synthesis and reduced muscle degradation

Following these data, deletion of endogenous Mecp2 with a specific small hairpin RNA interference reduced spine density after 96 h of expression and decreased the number of mature-shaped dendritic spines [374]

Several studies have suggested modulating this signaling cascade through miRNAs and natural compounds such as curcumin