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On the other hand, despite the observed GSH depletion and induction of GCLC protein expression in APAP-CYS treated cells, there was observed no significant ROS production after APAP-CYS treatment
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The results showed a significant decline in melanin production with glutathione use
Holland, S., et al
Pickart and colleagues proposed in a 1980 paper in Nature that the growth-modulating plasma tripeptide GHK may function by facilitating copper uptake into cells, rather than by acting on a dedicated cell-surface receptor [1]
