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Both agents reduce Caco2 cell viability in a dosedependent manner and significantly suppress oxidative phosphorylation function in mitochondrial complexes I and II [198]
Basically, all reducing groups of main cellular macromolecules can be targeted by ROS

Fetherolf et al., 2017)

PDE5i currently represent the first-line treatment for ED

doi: 10.1073/pnas.1309276110

doi: 10.1097/WOX.0b013e3182439613
