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Using these criteria, 28 of 32 participants (87.5%) qualified as high-TMAO producers (Supplementary Figure 7)

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Though there is not a standardized approach to multidisciplinary care of patients with ALS, expert consensus statements and society guidelines such as those from the European Academy of Neurology [97], United Kingdom National Institute for Health and Care Excellence (NICE), American Academy of Neurology [98, 99], and Japanese Society of Neurology [100], as well as national guidelines from Canada [100] and Iran [101], provide valuable frameworks for care

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