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Studies show that short- and long-term supplementation is safe and well tolerated in healthy individuals and in a number of patient populations, a paper released via Current Sports Medicine Reports asserted

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Elevated circulating IGF-1 led to an activation of the IGF-1PI3KAkt signalling pathway, causing augmented mTOR phosphorylation and higher phospho-FoxO/total FoxO ratio in skeletal muscle of LC supplemented rats [33]