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Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme

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ATP insufficiency also adversely affects neuronal function by disrupting Ca + regulation, impairing synaptic activity and neurotransmitter synthesis (7880)., and activating the AMPK-mTOR pathway to inhibit protein synthesis and cellular repair (81, 82)